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By delivering highly representative, real-world data from daily European transplant practices, the TOPVAS study provides an invaluable reference point for modern nephrology. It proves that excellent death-censored graft survival is achievable even when utilizing a high percentage of expanded criteria donor organs.

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The TOPVAS study aims to move beyond traditional clinical parameters and develop new, more precise methods for predicting transplant success. Here are some of its most significant aspects:

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: Evaluating estimated Glomerular Filtration Rate (eGFR) trajectories.

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In this phase, researchers analyzed transcriptomic profiles from zero-hour kidney biopsies (biopsies taken immediately after transplant) from 72 patients. These profiles helped identify a panel of molecular biomarkers correlated with clinical follow-up data to predict graft survival.

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